可降解植入水凝胶材料的应用及转化研究进展

Applications and translational research advances of degradable implantable hydrogels

摘要:

可降解植入水凝胶因其在实现预期体内功效后能够按预定程序进行降解吸收，避免了长期体内植入风险和二次手术去除创伤，已成为创面封堵、止血粘附、组织再生、智能生物传感器及药物载体等领域的研发热点。虽然围绕可降解植入水凝胶的基础研究众多，但成功实现临床转化的案例相对较少。本综述将系统梳理和分析国内、外在可降解植入水凝胶领域的研究进展，重点关注水凝胶结构和种类、临床研究进展，并结合具体转化案例，探讨这些进展在实际医疗应用中的转化路径和市场前景。期望为可降解植入水凝胶的转化提供思路和参考，助力该领域的发展。

Abstract:

Degradable implantable hydrogels have become a research hotspot in various fields, including wound sealing, hemostasis, tissue regeneration, smart biosensors, and drug delivery systems. This is attributed to their ability to degrade and absorb in a controlled manner after achieving their intended in vivo effects, thereby avoiding the risks associated with long-term implantation and secondary surgeries. However, although extensive fundamental research has been conducted on degradable implantable hydrogels, successful cases of clinical translation remain relatively rare. This review systematically summarizes and analyzes the research advances in degradable implantable hydrogels. It focuses on the structures and types of hydrogels, advances in clinical research, and examples of translational applications. Furthermore, it discusses translational pathways in clinical applications and market potential of these materials. This review aims to provide valuable insights and references for promoting the clinical translation of degradable implantable hydrogels, thereby contributing to the development of this field.