白癜风免疫治疗的研究进展

The therapeutic targets and clinical translational research in vitiligo

摘要:

白癜风是一种以皮肤色素脱失为主要表现的慢性自身免疫性疾病，对患者生活质量造成严重影响。近年来，针对白癜风的免疫学和分子生物学研究揭示了多个潜在治疗靶点，为疾病的治疗提供了新的策略。本文总结了 JAK/STAT通路、PDE-4、Wnt/β-catenin通路和IL-15等新型免疫治疗靶点及其靶向药物的研究进展，旨在为未来白癜风治疗靶点的临床转化提供参考。

Abstract:

Vitiligo is a chronic autoimmune disease characterized by depigmentation of the skin, significantly impacting patients' quality of life. Recent advances in immunological and molecular biological studies have identified numerous potential therapeutic targets for vitiligo, paving the way for novel treatment strategies. This article reviews the advancements in researching novel immunotherapy targets such as the JAK/ STAT pathway, PDE-4, Wnt/β-catenin pathway, and IL-15, along with their respective targeted drugs. The article aims to provide insights into the clinical translation of future therapeutic targets for vitiligo.