肺的神经免疫互作

Neuro-immune interaction of the lung

摘要:

免疫系统和神经系统在器官内部或跨器官之间的互动关系越来越受到关注。这种互动不仅在科学研究中得到证实，也在日常生活中有所体现：当组织损伤或者感染时，常见的红肿、疼痛等症状即为免疫系统和神经系统相互作用的结果；在肺炎或肺部感染等疾病情况下，患者常出现嗜睡、疲劳以及食欲减退等现象。肺作为人体重要的呼吸器官，通过其独特的结构和组织进行气体交换，同时肺也是机体抵御病原体入侵的第一道防线。免疫系统和神经系统对于肺的功能和稳态维持发挥重要的调控作用，影响多种呼吸道疾病的发生和进展。本文着重关注近期肺相关免疫系统和神经系统的互动研究进展，以期启示干预神经系统和免疫系统网络在呼吸道疾病治疗中的潜在应用。

Abstract:

The interaction between the immune system and the nervous system within and across organs has garnered increasing attention in the scientific community. Studies confirm that this interaction manifests not only in research but also in daily life: common symptoms such as swelling and pain during tissue damage or infection result from the mutual interactions between these systems. In conditions such as pneumonia or pulmonary infections, patients often experience symptoms like drowsiness, fatigue, and reduced appetite. The lungs, being vital respiratory organs, facilitate gas exchange through their unique structure and tissues, while also serving as the body's primary defense against pathogen invasion. The immune system and nervous system play pivotal roles in regulating lung function and maintaining homeostasis, influencing the onset and progression of various respiratory diseases. This article emphasizes recent advancements in understanding neuroimmune interactions specifically related to the lungs, aiming to illuminate potential applications for modulating the neuroimmune network in the treatment of respiratory diseases.