新生儿期MDSCs免疫调节作用的研究进展

Immunomodulatory role of MDSCs during the neonatal period

摘要:

在出生后，新生儿需立即应对肠道菌群的定植及大量外界抗原的刺激，因而维持免疫稳态对新生儿健康至关重要。髓源抑制性细胞是一群髓系来源且具有免疫抑制功能的固有免疫细胞，在促进肿瘤进展过程中发挥重要作用。近年研究发现，新生儿期髓源抑制性细胞具有重要的免疫保护功能。相比于肿瘤髓源抑制性细胞，新生儿髓源抑制性细胞显示出强大的抗菌活性，在预防新生儿炎症反应中发挥重要作用。本文总结了新生儿期髓源抑制性细胞的产生及特征，新生儿期髓源抑制性细胞的免疫调节作用和机制，以及其在新生儿炎症性疾病中的作用，以期为新生儿炎症性疾病的免疫治疗提供新策略。

Abstract:

Maintaining immune homeostasis is crucial for neonatal health following birth, as neonates encounter the colonization of gut flora and a plethora of external antigens. Myeloid-derived suppressor cells (MDSCs), a group of innate immune cells of myeloid origin with immunosuppressive functions, are known for their significant role in promoting tumor progression. Recent studies, however, have highlighted the critical immunoprotective functions of neonatal MDSCs. Unlike tumor-associated MDSCs, neonatal MDSCs exhibit strong antibacterial activity and play a vital role in preventing inflammatory responses in newborns. This review provides a comprehensive overview of the etiology, characteristics, immunomodulatory functions, and regulatory mechanisms of neonatal MDSCs, emphasizing their role in neonatal inflammatory diseases. This insight aims to provide new strategies for the immunotherapy of neonatal inflammatory diseases.