MACC1与肿瘤的研究进展

Research progress in MACC1 and cancer

摘要:

恶性肿瘤的发生严重威胁着人类的健康及生存，对于其发病机制及转移机制仍然不是十分清楚。结肠癌转移关联基因1 （Metastasis-Associated in Colon Cancer 1，MACC1） 是2009年发现的与结肠癌的发生密切相关的基因，不仅诱导肿瘤的发生、转移，且与肿瘤患者的预后及生存率明显相关，这主要与 MACC1 调节 HGF/c-Met 信号通路有关。在未来， MACC1有望成为肿瘤基因治疗的新靶点。本篇结合国内外的文献，就MACC1在肿瘤发生发展及转移过程的研究进展作一综述。

Abstract:

The occurrence of malignant tumor is a serious threat to human health and survival, but its pathogenesis and metastasis mechanism are still not very clear. MACC1 is a gene that was found in 2009 to be closely related to the development of colon cancer. The consensus is that MACC1 not only induces the occurrence and metastasis of tumors, but also significantly correlates with the prognosis and survival rate of tumor patients, which is mainly related to the regulation of HGF/c-Met signaling pathway by MACC1. MACC1 is expected to be a new target for tumor gene therapy in the future. In this review, the research progress of MACC1 in the process of tumor development and metastasis was reviewed.