细胞治疗在移植肝保存与功能修复中的研究进展

Research progress of cell therapy in the preservation and functional repair of donor livers

摘要:

肝移植是目前治疗终末期肝病最有效的手段。但供体器官短缺问题严重制约了临床肝移植的发展，缺血再灌注损伤及免疫排斥反应所造成的术后肝功能不全也使移植疗效受到显著影响。为改善供肝短缺现状，进一步提高肝移植疗效， 多种基于干细胞和体细胞的治疗策略已经逐渐应用于移植肝功能修复与提升。目前细胞治疗的干预时间点可分为移植肝离体前、机械灌注阶段和再灌注后。本文综合了现有研究，就细胞治疗在移植肝保存与功能修复中的作用及潜在机制进行综述，以助力细胞治疗在肝移植领域的应用与推广。

Abstract:

Liver transplantation is the most effective treatment for end-stage liver diseases. However, the shortage of donor livers severely restricts the application of liver transplantation, and the impairments of liver function caused by intraoperative ischemia reperfusion injury and postoperative immune rejection also significantly affect the therapeutic efficacy. In order to improve the shortage of donor livers and further improve the efficacy of liver transplantation, a variety of cell therapies based on stem cells or somatic cells have been tried to repair and improve donor liver function. At present, the time points for cell therapy can be divided into the stage before procurement of donor livers, machine perfusion stage and stage after reperfusion of donor livers. In this review, we summarize the efficacy and the underlying mechanisms of cell therapy in the preservation and function repair of donor livers, so as to facilitate the application and promotion of cell therapy in the field of liver transplantation.