T细胞在肺上皮细胞损伤与修复中的作用和机制

Function and mechanisms of T cells in the damage and repair of lung epithelial cells

摘要:

肺上皮细胞在呼吸系统中起着重要的保护作用。然而，各种病理因素如感染、创伤和炎症等可以导致肺上皮细胞的损伤，进而引发呼吸系统疾病。在肺上皮细胞损伤和修复过程中，T细胞扮演着关键角色，并通过接触或者释放多种免疫介质来参与这一过程。不同亚群的 T细胞分别承担着增强抗炎反应、清除感染的致炎作用以及促进血管新生和上皮细胞增殖的修复作用。本综述旨在总结T细胞在肺上皮细胞损伤和修复中的作用，并阐述其参与肺疾病发病和缓解的可能机制。

Abstract:

Lung epithelial cells play a protective role in the respiratory system. However, various pathological factors such as infection, trauma, and inflammation can lead to damage to lung epithelial cells, causing lung diseases. T cells play a key role in lung epithelial cells damage and repair, and participate in these processes by contacting with respiratory epithelial cells or releasing of various cytokines. Different subpopulations of T cells are responsible for enhancing anti-inflammatory responses, clearing infections, and promoting angiogenesis and epithelial cell proliferation. This review aims to summarize the role of T cells in lung epithelial cell damage and repair, as well as the mechanisms involved in the development and remission of lung diseases.