血管分泌因子调控肺再生与纤维化的机制研究进展

Research progress on the mechanism of angiocrine factors regulating lung regeneration and fibrosis

摘要:

哺乳动物肺受到损伤后具有一定的修复再生能力，但是这一能力会随着衰老以及损伤的持续进行被抑制，导致发生纤维化，目前肺纤维化仍缺乏有效的治疗方法。血管内皮细胞通过分泌不同的血管分泌因子 （Angiocrine Factors，AF） 能够对受损肺组织进行主动调节，平衡肺再生与纤维化。因此深入了解血管分泌因子的主动调节作用，能够为肺部疾病的治疗提供新的思路。本文主要综述了血管微环境对肺再生与纤维化调节机制的最新研究进展，同时本文也总结了研究肺部疾病的多种体内、体外模型，探讨了靶向编辑血管微环境促进肺再生的可能性。

Abstract:

Mammalian lungs have a certain ability to repair and regenerate following injury, which ability could decline with age and persistent damage, leading to fibrosis. Pulmonary fibrosis represents a major cause of death worldwide with limited therapeutic options. Endothelial cells balance the regeneration and fibrosis of damaged lung by orchestrating the diverse angiocrine factors. More knowledge about the active regulation of angiocrine factors has provide future treatment options for lung diseases. In this review, we mainly summarize the latest research progress on the regulatory mechanisms of vascular niche in lung regeneration and fibrosis. In addition, we also summarize various in / ex vivo models for studying lung disease, and discuss the potential of targeted editing of vascular niche to promote lung regeneration.