血液miRNA作为子宫内膜异位症诊断生物标志物的Meta分析

A Meta-analysis of blood miRNA as a diagnostic biomarker for endometriosis

摘要:

目的 通过 Meta分析评价血液 miRNA对子宫内膜异位症的诊断价值，确定血液 miRNA作为区分子宫内膜异位症无创性诊断生物标志物。方法 检索中英文数据库从建库至2022年9月关于血液miRNA诊断子宫内膜异位症的相关文献， 提取文献数据，采用Stata14.0软件和RevMan 5.4用于数据分析和质量评估。结果 共纳入了24篇相关文献，血液miRNA作为诊断子宫内膜异位症的总灵敏度为0.86，特异性为0.84，阳性似然比为5.3，阴性似然比为0.17，诊断优势比 (Diagnostic odds Rotio，DOR) 为31，曲线下面积 (Area Under the Curve，AUC) 为0.91，进行元回归及亚组分析，血清、亚洲和非洲人群、异位内膜表达上调的miRNA诊断EMs的准确价值较高。结论 血液miRNA可以作为子宫内膜异位症诊断生物标志物， 血清中表达上调的miRNA在亚洲和非洲人群中诊断子宫内膜异位症 (Endometriosis，EMs) 的诊断价值较高。

Abstract:

Objective The value of blood miRNA for the diagnosis of endometriosis was evaluated by Metaanalysis, for which it was identified as a non-invasive diagnostic biomarker to distinguish endometriosis. Methods English and Chinese language databases were searched for relevant literature on blood miRNAs for the diagnosis of endometriosis reported up until September 2022. The appropriate data was derived from the literature and analyzed and assessed using Stata14.0 and RevMan5.4. Results A total of 24 relevant papers were included. As a diagnostic tool for endometriosis, blood miRNA has an overall sensitivity of 0.86, specificity of 0.84, positive likelihood ratio of 5.3, negative likelihood ratio of 0.17, diagnostic odds ratio (DOR) of 31, and area under the curve (AUC) of 0.91. The research featured meta-regression and subgroup analysis, and the upregulation of expression by miRNA in blood serum, Asian and African populations had a higher accuracy value for diagnosing endometriosis. Conclusion Blood miRNAs can thus be used as diagnostic biomarkers for endometriosis, with the miRNAs upregulation in serum expression having a higher diagnostic value for diagnosing endometriosis in Asianand African populations.