多组学技术在人子宫内膜容受性中的研究进展

Advances in multi-omics research of human endometrial receptivity

摘要:

子宫内膜容受性是胚胎成功着床的关键，其异常是胚胎着床失败及不孕的主要原因，而传统的子宫内膜形态学观察方法无法充分确定子宫内膜容受性的状态。近年来，多组学技术的发展为生理病理条件下的子宫内膜功能特征研究提供了便捷有效的分析方法。因此，本文对转录组学、蛋白质组学及代谢组学等在人类子宫内膜容受性相关研究中的应用进行综述，旨在深入了解子宫内膜容受性并发掘新技术以强化子宫内膜植入窗口期检测的准确性，从而提高辅助生殖技术周期中怀孕的几率。

Abstract:

Endometrial receptivity is critical for successful embryo implantation, and endometrial receptivity abnormalities are major causes of embryo implantation failure and infertility. However, the traditional way cannot be adequately determined the condition of receptivity by morphological observation of endometrium. In recent years, the development of muli-omics technologies provides a convenient and effective analytical approach to study the functional characteristics of the endometrium in physiological and pathological conditions. This paper reviews the application of transcriptomics, proteomics and metabolomics in human endometrial receptivity studies, with the aim of gaining insight into endometrial receptivity and discovering new technologies to enhance the accuracy of endometrial implantation window detection, thereby improving the chances of pregnancy in assisted reproductive technology cycles.