母源肥胖与卵子质量

Maternal obesity and oocyte quality

摘要:

随着肥胖的流行，育龄期女性中肥胖比例也在持续上升，并对女性生殖健康产生严重影响。其中，肥胖对卵母细胞质量的影响一直备受关注。近年来，关于肥胖导致卵母细胞减数分裂阻滞，线粒体、内质网功能丢失以及表观遗传修饰的异常变化等情况被报道，其相应的机制也逐渐被揭示。本文将对母源肥胖影响卵子质量的研究进展进行综述，并结合已报道的机制提出潜在的干预靶标，以期改善肥胖引起的卵子质量低下、促进优生优育。

Abstract:

With an escalating global epidemic of obesity, the prevalence of obesity among reproductive women continues to rise. It has been widely reported that maternal obesity has profound effects on female reproduction. Of them, oocyte quality has been a major concern. In recent years, emerging evidence on maternal obesity has shown that meiosis damage, mitochondrial and endoplasmic reticulum dysfunction, and epigenetic modification changes occur in oocytes, and mechanisms are also being reported. Here we review the recent researches on the effects of maternal obesity on oocyte and embryo development, and propose the potential intervention targets and pathways to improve egg quality and reproductive outcome.