国家重点研发计划项目 (2021YFC2700100)；国家自然科学基金项目 (32130029；81725006；82171643；81971450；82071642)；中国博士后科学基金项目(2022M712147)
Infertility has become the third largest human disease in the world. With the wide application of in vitro fertilization (IVF), millions of people solve the problem of infertility by IVF every year. However, many patients experience recurrent IVF failures, displaying abnormal reproductive phenotypes (such as gamete development abnormalities, fertilization disorders, and early embryonic discontinuation). With the development of gene sequencing technology and the deepening of reproductive genetics research, more and more pathogenic genetic factors have been discovered. Genetic testing for these reproductive phenotypes can help patients make an early diagnosis and avoid repeated ineffective attempts. However, the treatment of the patients with recurrent IVF failures after genetic testing has become a new focus of attention. In this paper, the genetic factors, the treatment and potential intervention strategies of recurrent IVF failures in recent years are summarized to provide a reference for individualized diagnosis and treatment.