胎盘发育和子痫前期
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R321.4

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国家重点研发计划项目(2022YFC2702400);国家自然科学基金项目(81730040;32171115;82192872)


Placental development and preeclampsia
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    摘要:

    胎盘是妊娠期间胎儿和母体之间的桥梁,具有血流灌注、物质交换、免疫耐受和妊娠适应性调节等功能,对保障胎儿发育和母体健康发挥关键作用。胎盘发育不良与子痫前期等妊娠疾病密切相关。在本文中,我们总结了人类滋养层细胞分化和胎盘功能单元构建的最新研究进展,并讨论了可能导致子痫前期发病的因素。

    Abstract:

    Serving as the interface between the fetal and maternal environment during gestation, the placenta plays critical roles in the protection of the developing fetus and the maintenance of pregnancy. The placenta is responsible for blood perfusion and maternal-fetal material exchange, immune tolerance, and the regulation of pregnancy adaptation. Defects in placental development and functional maintenance are in tight association with adverse pregnancy outcomes such as preeclampsia. In this article, we reviewed recent advances on human trophoblast cell differentiation and the construction of placental functional units and discuss the pathogenic factors that may contribute to the occurrence of preeclampsia.

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  • 在线发布日期: 2023-01-04
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