微小残留病灶在非小细胞肺癌中的研究进展与应用
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

R734.2

基金项目:

上海申康医院发展中心新兴前沿技术联合攻关项目(SHDC12018122);上海市肺科医院创新研究群体项目(fkcx1904)


Current studies and potential applications of minimal residual disease in non-small cell lung carcinoma
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    部分非小细胞肺癌患者在早期治愈后会发生远期复发或转移,这可能与治疗后患者体内仍存在影像学或是实验室方法检测不到的肿瘤病灶,即微小残留病灶相关。这些肿瘤复发的潜在来源与患者较差的预后有着紧密的联系,因此, 在非小细胞肺癌病程中对这些病灶的监测十分重要。目前,针对微小残留病灶的检测主要依靠于液体活检,包括了循环肿瘤DNA检测、循环肿瘤细胞检测等方法。通过无创的检测手段,残留的肿瘤病灶为我们提供了肿瘤的进展状况以及具体的分子信息,预测了患者的预后状况,并进一步指导后续治疗方案。在这篇综述中,我们将探讨微小残留病灶发生发展的机制与影响,并关注对其的监测在临床治疗过程中可能的应用前景。

    Abstract:

    Long-term recurrences or metastases occur in some patients with non-small cell lung carcinoma after complete remission in the early stages. This phenomenon may be related to the presence of tumor lesions undetectable by radiographic or laboratory methods, which are called minimal residual disease. Poor prognosis of patients is closely associated with these potential sources of tumor recurrences, so it is essential to supervise these lesions during the treatment of non-small cell lung carcinoma. Currently, the detection of minimal residual disease mainly relies on liquid biopsy, including circulating tumor DNA detection, circulating tumor cell detection and other approaches. Through non-invasive detection methods, remaining tumor lesions provide us with the progression of the tumor and specific molecular information, predict the prognosis of patients, and further guide the follow-up treatment regimen. In this review, we will explore the mechanism and impact of the occurrence and development of minimal residual disease, and focus on its potential application value in the clinical treatment process.

    参考文献
    相似文献
    引证文献
引用本文
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2022-01-14
  • 出版日期:
《生物医学转化》编辑部郑重声明
关闭