温度敏感TRP通道:从2021年诺贝尔生理学或医学奖的温度感知机制的发现到心血管和代谢的调控
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{Q28}

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国家自然科学基金创新研究群体项目 (81721001)


The Nobel Prize in Physiology or Medicine 2021: temperaturesensitive TRP channels in the regulation of cardiovascular and metabolic function
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    摘要:

    2021年诺贝尔生理学或医学奖授予辣椒素受体TRPV1和薄荷醇感受器TRPM8通道的突破性发现,丰富了人们对热和冷触发的神经感知,及其适应环境温度机制的认识。温度敏感TRP通道——“热通道”TRPV1和“冷通道”TRPM8 不仅在神经系统有丰富表达,也存在于心血管、脂肪、肝脏和肌肉等组织器官,但其生物学意义并不清楚。为此,国内外学者探索温度敏感TRP通道调控心血管功能及糖脂代谢的作用,及其激动剂辣椒素和薄荷醇对心血管及代谢病的治疗效益。 2021年的诺贝尔奖使这个相对冷门的领域引起了较高的关注,并将推动其他多个领域的发展。

    Abstract:

    The 2021 Nobel Prize in Physiology or Medicine has be awarded to the breakthrough discovery of the capsaicin receptor TRPV1 and the menthol receptors TRPM8, which enrichis people's understanding of the neural perception of heat and cold trigger and the mechanism of adaptation to ambient temperature. Temperaturesensitive TRP channels "hot channel" TRPV1 and "cold channel" TRPM8 are not only richly expressed in the nervous system, but also exist in tissues and organs such as cardiovascular, fat, liver and muscle, but their biological significance is not clear. To this end, domestic and foreign researchers explored the role of temperature sensitive TRP channel in regulating cardiovascular function and glucolipid metabolism, and the therapeutic benefits of agonists capsaicin and menthol on cardiovascular and metabolic diseases. This year's prize has brought keen attention to a relatively obscure field and will spur progress in many others.

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  • 在线发布日期: 2022-01-14
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