小型猪模式动物在口腔颌面生物医学研究中的应用

The miniature pig: as an experimental model for dental and orofacial research

摘要:

小型猪牙颅颌系统解剖形态、生理功能及病理改变等与人类相近，其作为口腔颌面生物医学研究的模式动物具有明显优势。本文依托笔者课题组利用小型猪模式动物，在牙齿发育、唾液腺损伤防护、牙及其周围组织再生修复等领域进行的广泛探索研究，结合国内外利用小型猪进行的口腔颌面生物医学研究现状，阐述小型猪模式动物的特点及在口腔颌面生物医学研究中的应用前景。

Abstract:

Because its anatomical morphology, physiological structure and pathological mechanism of the oral and maxillofacial systems are more similar to human, miniature pig has significant advantages as a model ani‐ mal for oral and maxillofacial biomedical research. Based on the extensive research by our team in the areas of tooth development, salivary gland injury protection, tooth and supporting tissue regeneration and restoration, as well as the progress of oral and maxillofacial biomedical research using miniature pigs by other groups, we review the applications of miniature pig model in fundamental and translational research.