双酚S的环境污染现状及对脂质代谢紊乱的影响
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国家重点研发计划 (2019YFA0802701)


Environmental pollution of bisphenol S and its effect on abnormal lipid metabolism
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    摘要:

    双酚S (Bisphenol S,BPS) 是双酚A (Bisphenol A,BPA) 的替代品,被广泛用于制造各种聚合物。由于其广泛的使用,造成的环境污染已经严重威胁生态环境和人体健康。近年来,BPS所引起的脂质代谢紊乱逐渐引起大家的关注。 本文对BPS导致环境污染的现状及人群暴露风险进行总结,并从其对脂质合成、转运和降解基因的表达,代谢组学以及对过氧化物酶体增殖物激活受体γ (PPARγ)的作用等方面来探讨BPS所致脂质代谢异常的潜在机制。

    Abstract:

    Bisphenol S (BPS), a substitute of bisphenol A (BPA), is widely used for manufacturing different polymers. Due to its wide range of applications, BPS caused pollution has seriously threatened the ecological environment and human health. In recent years, the relationship between BPS and lipid metabolism disorder has attracted more and more attention. This paper summarizes the distribution of BPS in the environment and human exposure risk, as well as the possible mechanisms of the association between BPS and dyslipidemias, including the expression of lipid synthesis, transport and degradation genes, metabolomics, and effect on peroxisome proliferator activated receptors γ (PPARγ).

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  • 在线发布日期: 2020-12-31
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