病理性心脏重塑的代谢变化与干预靶点

Metabolic alterations and therapeutic targets of Pathological cardiac remodeling

摘要:

全球心血管疾病发病率和死亡率不断增加。病理性心脏重塑在心血管疾病发生发展中发挥重要作用。越来越多的研究关注在病理性心脏重塑中心脏代谢的改变。心脏肥大和心力衰竭时心脏代谢紊乱，心肌从脂肪酸为主的代谢特征转变为葡萄糖为主的代谢特征，心脏结构和功能发生异常。本文综述了病理性心脏重塑中脂肪酸、葡萄糖和氨基酸不同底物代谢变化特征及其对心脏功能的影响。基于病理性重塑的代谢改变分析潜在干预靶点，从代谢调节的角度为药物研发提供新路径和理论依据，以改善心脏肥大和心力衰竭患者的预后。

Abstract:

The morbidity and mortality of cardiovascular diseases are increasing globally. Pathological car-diac remodeling plays an important role in the development of cardiovascular diseases. More and more investiga-tions focus on the alterations of cardiac metabolism in pathological cardiac remodeling. Cardiac substrate metabo-lism is severely impaired during cardiac hypertrophy and heart failure, a shift from fatty acid metabolism to glu-cose metabolism, resulting in aggravated cardiac dysfunction. This review analyzes the relationship among the me-tabolism of different substrates in pathological cardiac remodeling. Based on these metabolic changes, we summa-rize the pharmacological agents, and raise new drug development strategies from the perspective of metabolic reg-ulation, leading to an improved prognosis and treatment of patients with cardiac remodeling diseases.