Gastric cancer is a high incidence cancer in China. Surgical treatment is regarded as the cornerstone of gastric cancer treatment. Surgical research has been focusing on endoscopic surgery and lymph node dissection. At the same time, with the continuous innovation of immunotherapeutic and targeted therapeutic drugs, the mode of perioperative treatment and Ⅳ stage treatment has made great changes and progress, and the survival benefit of patients has been improved. In addition, with the rapid development of cancer biology and next-generation sequencing, accurate stratification of patients' populations and accurate drug use based on patients' subpopulation have been providing hopes for gastric cancer patients.