Kawasaki disease (KD) mostly occurs in children under 5 years of age, and intravenous immunoglobulin (IVIG)-resistant children with KD are at higher risk of cardiovascular complications, and early identification and active treatment of KD children with IVIG resistance can effectively improve their prognosis. Combined with the latest literature, this review summarizes the single indexes and predictive models of IVIG-resistant KD and provides the evidence for the diagnosis and treatment of children with KD.