Bisphenol S (BPS), a substitute of bisphenol A (BPA), is widely used for manufacturing different polymers. Due to its wide range of applications, BPS caused pollution has seriously threatened the ecological environment and human health. In recent years, the relationship between BPS and lipid metabolism disorder has attracted more and more attention. This paper summarizes the distribution of BPS in the environment and human exposure risk, as well as the possible mechanisms of the association between BPS and dyslipidemias, including the expression of lipid synthesis, transport and degradation genes, metabolomics, and effect on peroxisome proliferator activated receptors γ (PPARγ).