At present, medical ultrasound technology is gradually developing from the traditional imaging of tissue and organ structure based on wave effect of ultrasound, and the treatment of diseased tissue based on thermal and cavitation effects, to the direction of multi-functional integration of diagnosis and treatment. Therefore, as one of the most important biological effects, the mechanical effect of ultrasound (i.e. acoustic radiation force) has attracted more and more attention from scientific researchers and medical staffs. Benefiting from the in-depth understanding of the theory and mechanism of ultrasonic mechanical effect, as well as the rapid development of information and electronic technology, a variety of new ultrasonic diagnosis and treatment technologies based on acoustic radiation force have emerged in recent years, which have greatly expanded the application of ultrasound in clinics. For example, ultrasound elastography that can quantitatively measure the tissue stiffness and image its distribution, which can provide early screening for liver cirrhosis and breast cancer; as well as ultrasound neuromodulation that can non-invasively regulate the state of nerve cells in the brain, which can provide unique tools for brain disease treatment and neuroscience research. This article will systematically introduce the representative achievements of these new medical ultrasound technologies based on the mechanical effect of ultrasound in recent years, and analyze their future development directions.